B2582 - Genetics of traits related to autism spectrum condition - 03/03/2017
B number:
B2582
Principal applicant name:
Varun Warrier | University of Cambridge
Co-applicants:
Prof. Thomas Bourgeron, Aicha Tigany Massrali, Bhismadev Chakrabarti, Roberto Toro, Dwaipayan Adhya, Florina Uzefovsky, Mr Varun Warrier
Title of project:
Genetics of traits related to autism spectrum condition
Proposal summary:
Autism and other psychiatric condition can be viewed as being dimensional. Individuals diagnosed with autism have difficulties in empathizing and emotion recognition, while have preserved or higher than average systemizing abilities when compared to regular controls. We have collaborated with 23andMe to perform a GWAS of three psychological traits - empathy, systemizing and theory of mind. In this study, we will use data from this study and other measures of communication ability, occupation, empathy, and theory of mind to identify genes that contribute to these traits. We will investigate if these traits can be used to stratify individuals within the autism spectrum.
Date proposal received:
Saturday, 28 November, 2015
Date proposal approved:
Wednesday, 2 December, 2015
Keywords:
Mental health - Psychology, Psychiatry, Cognition, Cognitive impairment, Mental health, Speech/language problem, GWAS, Statistical methods, Childhood - childcare, childhood adversity, Cognition - cognitive function, Communication (including non-verbal), Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Psychology - personality