B2586 - PheWAS of multiple sclerosis genetic risk score - 04/12/2015

B number: 
B2586
Principal applicant name: 
Lavinia Paternoster | MRC IEU, University of Bristol (United Kingdom)
Co-applicants: 
Ms Ruth Mitchell
Title of project: 
PheWAS of multiple sclerosis genetic risk score
Proposal summary: 

Genetic variants for multiple sclerosis (MS) have been identified. We will calculate MS genetic propensity scores for ALSPAC mothers and offspring. We will screen ALSPAC to identify phenotypes that are associated with genetic propensity to MS in individuals without the disease.

Date proposal received: 
Monday, 30 November, 2015
Date proposal approved: 
Wednesday, 2 December, 2015
Keywords: 
Genetics, Multiple sclerosis, Statistical methods, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc.