B2592 - Do Genetic Factors influence response to anti-VEGF treatment in age-related macular degeneration - 15/12/2015
B number:
B2592
Principal applicant name:
Amanda Churchill | University of Bristol (Avon)
Co-applicants:
Dr Nic Timpson
Title of project:
Do Genetic Factors influence response to anti-VEGF treatment in age-related macular degeneration
Proposal summary:
Age-related macular degeneration (AMD) is the commonest cause of visual loss in the retired population. Intra-ocular anti-VEGF injections are very effective in treating AMD with partial visual recovery but about 26% individuals have a poor or no response to the treatment. We wish to determine whether DNA markers can be used to predict how an affected individual will respond to this treatment. Alternatives treatments are available but currently only given when anti-VEGF injections have been tried and failed. If it were possible to predict poor responders to anti-VEGF injections from the outset then an alternative treatment could be offered to these individuals without delay and with the potential for a better visual prognosis.
Date proposal received:
Monday, 7 December, 2015
Date proposal approved:
Wednesday, 9 December, 2015
Keywords:
Genetics, Vision - age related macular degeneration, GWAS, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Vision