B2642 - Parenting practices in association with ADHD and adolescent outcomes - 14/03/2016

B number: 
B2642
Principal applicant name: 
Rafael Gonzalez | Imperial College London (United Kingdom)
Co-applicants: 
Glyn Lewis
Title of project: 
Parenting practices in association with ADHD and adolescent outcomes
Proposal summary: 

Childhood maltreatment is a prevalent risk factor associated with long-term morbidity and mortality, mental health problems, and adult violence[1-2]. In 2014 alone, 6.6 million children in the U.S. were involved in referrals where there was alleged maltreatment, including 702,000 victims of child abuse and neglect[3]. Psychiatric morbidity attributed to early maltreatment is extensive and often severe[4-6]. Recent research reveals associations between adverse childhood experiences including physical abuse and neglect with ADHD[7-8]. ADHD is a psychiatric disorder with childhood onset (<12), characterised by its dimensions of hyperactivity/impulsivity and inattentiveness[9], and its high heritability is well documented[10]. ADHD is also associated with problems related to executive functioning, including the ability to self-regulate[11].

Quality of parental care, including harsh parenting is a risk factor for the development of behavioural problems early in life[12]. Parenting and family factors have been recognised to affect the course of ADHD, and the development of comorbidity. In addition, parents of children with ADHD report significantly more stressful and dysfunctional parent-child interactions than do parents of children without ADHD[13].

Studies examining the relationship between ADHD and maltreatment have reported significant associations[7-8, 14-15], however most of these studies have used cross-sectional designs, limiting any directional or causal interpretation. Most also lack essential confounders such as family-level and psychiatric factors, and unexplained genetic variance. Early maltreatment as a distinct risk factor for ADHD has not been effectively examined. Moreover, the role of parenting behaviours and early maltreatment with ADHD has not been systematically studied using well-characterised population data.

Our aim is to the examine the role of parenting practices, with an emphasis on maladaptive parenting and early child abuse, with the developmental course of ADHD symptoms and its symptom trajectories from early childhood through adolescence, and associated adverse outcomes. We aim to perform a systematic evaluation of the role of these exposures at the population level using representative longitudinal data.

1. Gilbert R et al. Burden and consequences of child maltreatment in high-income countries. Lancet. Jan 3 2009;373(9657):68-81.
2. Gonzalez RA et al. Childhood maltreatment and violence: Mediation through psychiatric morbidity. Child Abuse Negl. Jan 21 2016;52:70-84.
3. U.S. Department of Health & Human Services AfCaF, Administration on Children, Youth and Families, Children’s Bureau., ed2016. Child Maltreatment 2014.
4. Horwitz AV et al. The impact of childhood abuse and neglect on adult mental health: a prospective study. J Health Soc Behav. Jun 2001;42(2):184-201.
5. Johnson JG et al. Childhood maltreatment increases risk for personality disorders during early adulthood. Arch Gen Psychiatry. Jul 1999;56(7):600-606.
6. Bebbington P et al. Childhood sexual abuse and psychosis: data from a cross-sectional national psychiatric survey. Br J Psychiatry. Jul 2011;199(1):29-37.
7. Fuller-Thomson E et al. The relationship between early adversities and attention-deficit/hyperactivity disorder. Child Abuse Negl. Apr 3 2015.
8. Guendelman MD, Owens EB, Galan C, Gard A, Hinshaw SP. Early-adult correlates of maltreatment in girls with attention-deficit/hyperactivity disorder: Increased risk for internalizing symptoms and suicidality. Dev Psychopathol. Feb 27 2015:1-14.
9. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: Author; 2013.
10. Thapar A et al. The genetics of attention deficit hyperactivity disorder. Hum Mol Genet. Oct 15 2005;14 Spec No. 2:R275-282.
11. Velez-Pastrana MC, Gonzalez RA et al. Psychometric Properties of the Barkley Deficits in Executive Functioning Scale: A Spanish-Language Version in a Community Sample of Puerto Rican Adults. Psychol Assess 2015.
12. Miner J et al. Trajectories of externalizing behaviour from age 2 to age 9: Relations with gender, temperament, ethnicity, parenting and rater. Developmental Psychology. 2008; 44(3): 771-86.
13. Briscoe-Smith AM et al. Linkages between child abuse and attention-deficit/hyperactivity disorder in girls: behavioral and social correlates. Child Abuse Negl. Nov 2006;30(11):1239-1255.
14. Linares LO et al. The course of inattention and hyperactivity/impulsivity symptoms after foster placement. Pediatrics. 2010;125(3):e489-e498.
15. Ouyang L et al. Attention-deficit/hyperactivity disorder symptoms and child maltreatment: A population-based study. The Journal of Pediatrics. 2008;153(6):851-856.

Date proposal received: 
Sunday, 6 March, 2016
Date proposal approved: 
Wednesday, 9 March, 2016
Keywords: 
Psychology