B2656 - Life Cycle - EuroKIDs cohort a Horizon2020 EU application - 07/04/2016

B number: 
B2656
Principal applicant name: 
Deborah Lawlor | MRC IEU at the University of Bristol and School of Social and Community Medicine (United Kingdom)
Co-applicants: 
Dr Abigail Fraser
Title of project: 
Life Cycle - EuroKIDs cohort a Horizon2020 EU application
Proposal summary: 

Birth/pregnancy cohorts are studies that recruit mothers during pregnancy or parents and their children at the time the child is first born and collect important health and wellbeing data on them across all of their life, if possible to obtain grant funds to do so. They are very important to understand how where we come from (e.g. what jobs are parents do, which country and city we were born in), what we are exposed to (for example traffic fumes), what we do (e.g. what we eat, how much exercise we do, how well we do at school) and our biological make up (e.g. genetics and epigenetics) act together to influence whether we live a long healthy life, or have health problems and also how well we feel in ourselves and what we go on to do (what job we have as an adult, how many children we have etc.). They are also useful for seeing how large scale things like the global economic crisis can affect health and wellbing.
In Europe there are lots of such cohorts, including the Avon Longitudinal Study of Patents and Children (ALSPAC; also known as Children of the 90s), which is considered to be one of the best of these types of studies. Each of these studies alone have increased our knowledge of what causes some people to be well and others not and what things are important for general wellbeing. But together they can achieve a lot more. We want to bring these cohorts together in order to better understand how what happens to us when we are in the uterus (when our mothers are pregnant) and what happens to us at birth and early childhood influences how we grow, how fat or thin we are, whether we have risk factors for heart disease, diabetes, asthma or other breathing problem, depression, schizophrenia or other mental health problems. By putting all of these cohorts together we will also be able to determine what early life risk factors affect getting diseases in later adulthood.

Date proposal received: 
Wednesday, 23 March, 2016
Date proposal approved: 
Tuesday, 5 April, 2016
Keywords: 
Epidemiology, Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Diabetes, Eating disorders - anorexia, bulimia, Hypertension, Mental health, Obesity, Respiratory - asthma, Cardiovascular health (NB needs adding to the list), Epigenetics, GWAS, Mass spectrometry, NMR, Statistical methods, Note we will NOT be collecting any new data - but I have ticked those that have some relevance to data we will use that already exists I think we need some new additions here that fall between GWAS and genomics-structural variants - would suggest adding - 'Mendelian randomization' and 'candidate SNP analyses' I ticked GWAS but we will not be doing any GWAS but will use data from the genome wide panel to do MR -- lots of applications to ALSPAC must be the same , Ageing, Blood pressure, BMI, Cardiovascular, Development, Metabolic - metabolism, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc.