B2662 - Association of mitochondrial copy number with phenotypes in the UK10K cohort samples - 19/04/2016
B number:
B2662
Principal applicant name:
Inês Barroso | Wellcome Trust Sanger Institute
Co-applicants:
Dr Eleanor Wheeler, Miss Chen Li
Title of project:
Association of mitochondrial copy number with phenotypes in the UK10K cohort samples
Proposal summary:
We are planning to replicate a finding from a recent paper (Ding et al. 2015, PMID:26172475) which found a correlation between mitochondrial copy number (the number of copies of mitochondrial DNA) with waist circumference and waist-hip ratio using whole-genome sequence data from the UK10K cohort samples.
Date proposal received:
Wednesday, 30 March, 2016
Date proposal approved:
Tuesday, 19 April, 2016
Keywords:
Genetics, Obesity, Body shape/size., DNA sequencing, Statistical methods, Software package mitoAnalyzer, Ding et al. (2015) PMID:26172475 will be used to estimate mtDNA copy number., Biological samples -e.g. blood, cell lines, saliva, etc., BMI, Cardiovascular, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Metabolic - metabolism