B2688 - Parenting in early life epigenetic change and child behavior - 18/05/2016

B number: 
B2688
Principal applicant name: 
Katarzyna Kordas | SUNY at Buffalo (USA)
Co-applicants: 
Dr. Matthew Suderman, Dr. Rebecca Pearson, Prof. Caroline Relton, Dr. Daniel Gaile, Dr. Marc Bornstein
Title of project: 
Parenting in early life, epigenetic change and child behavior
Proposal summary: 

Parenting is intricately entwined with child development and many examples could be cited with regards to the links between parenting and child behavioral, cognitive, and health outcomes. Yet, it is unclear how parenting actually translates into the myriad outcomes studied to date. Although biological underpinnings are postulated, including altered stress response, brain maturation, and epigenetic signatures, these mechanisms are not well worked out. With respect to epigenetic mechanisms, there are still gaps in understanding how early parenting of human children affects their DNA methylation, whether the normative variation in parenting will result in any epigenetic changes, and whether parenting works THROUGH DNA methylation to produce behavioral outcomes in children.

Date proposal received: 
Thursday, 12 May, 2016
Date proposal approved: 
Wednesday, 18 May, 2016
Keywords: 
Genetics, Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Epigenetics, Childhood - childcare, childhood adversity, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Offspring, Parenting