B2689 - Using Mendelian Randomization framework to determine whether there is a causal association between early menarche depression - 18/05/2016

B number: 
B2689
Principal applicant name: 
Rebecca Lawn | MRC IEU, Bristol university, School of Experimental Psychology (United Kingdom)
Co-applicants: 
Sarah Lewis, Carol Joinson, Carolina Bonilla
Title of project: 
Using Mendelian Randomization framework to determine whether there is a causal association between early menarche & depression
Proposal summary: 

This project is a MRC IEU PhD student mini project.

We have previously shown that an early onset of menarche is associated with increased levels of depression in 14 year old girls and we found evidence that this effect it causal. It is unclear, however, whether this effect persists beyond adolescence.

Date proposal received: 
Monday, 16 May, 2016
Date proposal approved: 
Wednesday, 18 May, 2016
Keywords: 
Epidemiology, Depression, Gene expression, Development, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Mothers - maternal age, menopause, obstetrics, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Psychology - personality, Puberty