B2710 - Imputation of ALSPAC Fathers and ReImputation of ALSPAC Mothers and Children - 01/07/2016
B number:
B2710
Principal applicant name:
George McMahon | ALSPAC (United Kingdom )
Co-applicants:
Dr. Nic Timpson
Title of project:
Imputation of ALSPAC Fathers and ReImputation of ALSPAC Mothers and Children
Proposal summary:
ALSPAC has contributed to a large number of genomewide association studies (GWAS). We have these data imputed to the recent reference panels for 9321 mothers and 9115 children (1000 genomes). We currently also have Fathers data, which is yet to be imputed and therefore cannot be used as effectively as possible (for example a typical contribution to a GWAS consortium requires imputed data). Furthermore our current imputations need to be continually updated as new opportunities arise and re-imputation with the latest available 1000 Genomes panel is necessary to continue contributing to large meta-analyses.
Date proposal received:
Thursday, 30 June, 2016
Date proposal approved:
Thursday, 30 June, 2016
Keywords:
Genetics, GWAS, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc.