Paracetamol (Acetaminophen) is a common “over-the-counter” NSAID, which is commonly regarded as safe when taken in in recommended doses. The most common side effects of paracetamol over-use is acute liver failure.
New large epidemiological studies suggest that there may be second generation effects when paracetamol is taken by the mother during pregnancy. The current evidence have linked maternal pregnancy exposure of paracetamol to increased risk of ADHD (ADD) and wheeze/asthma in the children. We aim to explore the effect of maternal paracetamol intake during pregnancy on DNA methylation in offspring at birth. This project forms part of a collaboration where test statistics will be used in meta-analysis with additional cohorts.