Analyses of DNA methylation has to date focused on single-point analyses such as epigenome-wide association studies, that test the association of each CpG individually with a phenotype. While this can be informative, they result in a large number of tests, and do not make use of the known stucture of the epi-genome. Also, there is other information, such as about biological pathways (available in online databases such as Reactome) that may be informative.