B2733 - Impulsivity as a Genetic Mechanism of Risk within the ALSPAC Cohort - 25/01/2017
B number:
B2733
Principal applicant name:
James MacKillop | Peter Boris Centre for Addictions Research, McMaster University (Canada)
Co-applicants:
Marcus Munafo
Title of project:
Impulsivity as a Genetic Mechanism of Risk within the ALSPAC Cohort
Proposal summary:
Impulsivity is a multidimensional psychological trait that has been linked to addictive disorders and other mental health conditions. There is increasing evidence that specific forms of impulsivity are influenced by genetic variation, suggesting that these traits may be one intervening mechanism for genetic influences on health. However, most of the studies to date have had relatively small sample sizes and have not applied novel genome-wide approaches. Assessing impulsivity within the ALSPAC cohort will permit us to address these limitations and conduct a high-resolution investigation of impulsivity as a genetically-influenced risk factor for addictive disorders and related conditions.
Date proposal received:
Thursday, 18 August, 2016
Date proposal approved:
Monday, 5 September, 2016
Keywords:
Mental health - Psychology, Psychiatry, Cognition, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Eating disorders - anorexia, bulimia, Mental health, Obesity, GWAS, Statistical methods, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Blood pressure, BMI, Childhood - childcare, childhood adversity, Cognition - cognitive function, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Intelligence - memory, Psychology - personality