How much alcohol is safe to drink during pregnancy? Many studies focussed on answering this question report discordant results. While the deleterious effect of heavy alcohol consumption by pregnant mothers on their offspring is well established publicly and scientifically, the effect of moderate or intermittent consumption is less well substantiated. This uncertainty leads to unclear advice being delivered by global health organisations and general practitioners. This proposal aims to move towards understanding the influence of prenatal alcohol exposure patterns on newborn children and on their life course, through analysis of epigenetic data arising from the Avon Longitudinal Study of Parents and Children (ALSPAC). This proposal will focus on analysing the multivariate DNA methylation data from offspring and their mothers’ survey data in ALSPAC using appropriate statistical models in order to make correct inference about the influence of prenatal alcohol exposure patterns.