The genes associated with vitamin D levels can be utilised to infer whether vitamin D causally effects a particular outcome (for example disease). Traditionally, these genes have been identified by looking at what genes effect the level of vitamin D in circulating blood. This method is likely to miss genes that are important and does not take into account the active form of vitamin D that enters human cells to cause a response. This project will look at diseases and other body chemicals that are known to be linked with vitamin D to identify genes that control the biochemistry around vitamin D.