B2754 - Imputation of the ALSPAC data to the new HRC panel using the Mach algorithm - 28/09/2016

B number: 
B2754
Principal applicant name: 
George McMahon | Avon Longitudinal Study of Parent and Children
Co-applicants: 
Nicholas Timpson, Lavinia Paternoster
Title of project: 
Imputation of the ALSPAC data to the new HRC panel using the Mach algorithm
Proposal summary: 

ALSPAC has contributed to a large number of genomewide association studies (GWAS). We have these data imputed to the recent reference panels for 9,321 mothers and 9,115 children (1000 genomes) and recently to the latest release of the 1000 Genomes (B2710). There is a further requirement to impute this data to the Haplotype Reference Consortium (HRC), a much larger reference panel of over 60,000 haplotypes to contribute to ongoing international GWAS studies. Furthermore, imputation can vary in quality according to imputation algorithm. Imputation using the MACH algorithm will bring ALSPACs HRC imputed data in line with other large genetic studies.

Date proposal received: 
Friday, 23 September, 2016
Date proposal approved: 
Wednesday, 28 September, 2016
Keywords: 
Genetics