Psychosis-like symptoms (PLIKS) are experienced by around 15 % of individuals in childhood and adolescence (Zammit et al., 2008) and research suggests that the experience of such symptoms might increase the risk of developing psychotic disorder during adulthood (Fisher et al., 2013; Poulton et al., 2000; van Os, Linscott, Myin-Germeys, Delespaul, & Krabbendam, 2009). However, little is known about early biological predictors (such as DNA methylation) of PLIKS. C-reactive protein (CRP) is an inflammation marker protein found in blood. CRP has been suggested to be involved in psychotic disorders such as schizophrenia (Miller, Culpepper, & Rapaport, 2014). Investigating how DNA methylation linked to CRP at birth associates with PLIKS in adolescence might shed light into potential biological risk pathways for psychosis.