B2767 - Heritability and polygenic risk of reading performance - 16/01/2017

B number: 
B2767
Principal applicant name: 
Jeffrey R. Gruen | Yale University School of Medicine (United States)
Co-applicants: 
Chintan Mehta, Andrew Adams, Dongnhu Truong
Title of project: 
Heritability and polygenic risk of reading performance
Proposal summary: 

Identifying and treating students with learning difficulties is an important public health priority. There is considerable evidence that genetic variants play a major role in the development of reading and language behaviors with twin studies placing heritability estimates of such traits between 45-85% . We seek to understand how genetic variants’ influence cognitive traits and vary with age and gender in contrast to environmental factors such as socioeconomic status. We also want to test the strength of polygenic scores, derived from previous studies, at predicting reading performance in the ALSPAC sample.

Date proposal received: 
Tuesday, 18 October, 2016
Date proposal approved: 
Wednesday, 2 November, 2016
Keywords: 
Genetics, Cognitive impairment, Learning difficulty, Speech/language problem, Reading disabilities, GWAS, Statistical methods, Cognition - cognitive function, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Statistical methods