T1D is an unrelenting chronic disease of childhood that places a substantial burden on children and their families. This onus is increasing rapidly as the annual incidence rate of T1D is growing by ~5% per year in developed countries, such that by 2020 the number of children in Europe with T1D will increase by 70% from 2005 levels. T1D leads not only to a reduced lifespan by 12 years, but also to increased rates of renal failure requiring life-long dialysis, blindness, limb amputation, coronary heart disease and stroke. This study aims to use ALSPAC genotype data as controls in the replication of genetic association findings found to be associated with risk of T1D.