Quantitative trait loci (QTLs) studies have been successful identifying regions of the genome associated with inter-individual differences in DNA methylation. A common approach to explore the impact of genetic variants on DNA methylation is based on assessing differences in the mean methylation levels. However, QTLs may also contribute to the amount of variability of epigenetic marks (var QTLs). We identified var QTLs for DNA methylation in whole-blood using MZ twins-discordance as a measure of variability and are interested in the replication of these var meQTLs in an independent cohort.