B2808 - DNA methylation networks epigenetic changes during development across generations and with environmental exposures - 26/04/2017
B number:
B2808
Principal applicant name:
Sarah H Watkins | IEU, School of Social and Community Medicine, University of Bristol (UK)
Co-applicants:
Miss. Sarah H Watkins, Dr Josine Min, Dr Nic Timpson
Title of project:
DNA methylation networks: epigenetic changes during development, across generations, and with environmental exposures
Proposal summary:
DNA methylation is a chemical change to our DNA that can determine whether a gene is expressed or not. We know DNA methylation changes naturally as we age, and we also know that it can change in response to the environment. This project will describe these changes in methylation data from the ALSPAC cohort. We will then look at how DNA methylation differs between children and their mothers, and how methylation changes as they age. I will also look at how aspects of the environment, such as smoking and diet, can change patterns of methylation, and whether these changes are the same or different across generations.
Date proposal received:
Friday, 16 December, 2016
Date proposal approved:
Monday, 9 January, 2017
Keywords:
Bioinformatics, Epigenetics, Microarrays, Statistical methods, Ageing, Development, Environment - enviromental exposure, pollution, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Mothers - maternal age, menopause, obstetrics, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc.