B2820 - Is Endothelial Function Involved in Stroke and Dementia - 25/01/2017

B number: 
B2820
Principal applicant name: 
Matthew Traylor | University of Cambridge (United Kingdom)
Co-applicants: 
Professor Hugh Markus
Title of project: 
Is Endothelial Function Involved in Stroke and Dementia?
Proposal summary: 

This project is part of a larger EU-funded funded project (CoSTREAM), aimed at identifying shared mechanisms which lead to both stroke and Alzheimer's Disease. One such mechanism we are investigating is endothelial function – the normal response of vessels to being supplied with blood. In this project, we aim to test whether changes in endothelial function are involved in Alzheimer's Disease and stroke. We plan to do this by testing whether genetic factors that alter endothelial function also influence risk of Alzheimer's Disease and stroke.

Date proposal received: 
Monday, 16 January, 2017
Date proposal approved: 
Thursday, 19 January, 2017
Keywords: 
Genetics, Cognitive impairment, GWAS, Mendelian Randomization Polygenic Risk Scoring, Ageing, Cardiovascular, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc.