B2838 - The developmental role of metabolism appetite and growth in eating disorders exploring novel longitudinal risk pathways - 03/04/2017

B number: 
B2838
Principal applicant name: 
Nadia Micali | UCL Institute of Child Health (Uk)
Co-applicants: 
Cynthia Bulik, Bianca De Stavola, Debbie Lawlor, Diana Santos Ferreira, Ruth Loos, Gerome Breen
Title of project: 
The developmental role of metabolism, appetite and growth in eating disorders: exploring novel longitudinal risk pathways
Proposal summary: 

The Eating Disorders (full and partial syndrome anorexia nervosa and bulimia nervosa and binge eating disorder) are life-threatening illnesses that start in adolescence and affect between one and two in ten adolescents and young adults. There is a lack in our understanding of why eating disorders develop, which affects our ability to develop treatment and adequately prevent eating disorders. This project builds on our preliminary data showing that metabolism and growth might play a role in the development of eating disorders; and aims to test the hypothesis that metabolic function, appetite and growth factors might precede onset of eating disorders. We also aim to explore whether these factors might be related to individuals’ genetic make up, using novel methodologies and based on novel genetic findings. This study will be fundamental in starting to understand new risk mechanisms for adolescent and young adult eating disorders that can be further investigated in larger and more detailed studies following this project.

Date proposal received: 
Wednesday, 8 February, 2017
Date proposal approved: 
Wednesday, 15 February, 2017
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Eating disorders - anorexia, bulimia, GWAS, Metabolomics