B2840 - Depot specific effect of pre-pubertal IGF-II on post pubertal fat distribution in ALSPAC cohort - 07/03/2017
B number:
B2840
Principal applicant name:
Andy Ness | University of Bristol (Avon)
Co-applicants:
Dr.Maiadah ALfares, Dr Sam Leary, Prof Andy Ness
Title of project:
Depot specific effect of pre-pubertal IGF-II on post pubertal fat distribution in ALSPAC cohort
Proposal summary:
Insulin like growth factor II (IGF-II) is a hormone. IGF-II levels in the human circulation are maintained at high levels throughout life unlike those of rodents. IGF-II has been strongly linked to obesity in genetic studies but its metabolic role is still far from understood. We were able to confirm using fat biopsies from children that IGF-II is a key regulator of fat cell biology. Our results suggest it acts as a buffer to excess visceral fat accumulation in children.
Date proposal received:
Monday, 13 February, 2017
Date proposal approved:
Wednesday, 15 February, 2017
Keywords:
Epidemiology, Obesity, Statistical methods, BMI, Cohort studies - attrition, bias, participant engagement, ethics, Childhood - childcare, childhood adversity, Metabolic - metabolism