Most research on parental job loss has focused on the negative outcomes for the adults experiencing it, but much less is known about the effects on their children (Kalil, 2013). Emerging evidence suggests that parental job loss increases the likelihood of poor academic outcomes (e.g., school dropout, grade retention, Kertezi & Kezdi, 2007; Stevens & Schaller, 2011), but the mediating processes for these effects are not well characterized. Furthermore, we know little about the consequences of parental job loss for the offspring’s mental and physical health, or about factors that may promote resilience for youth exposed to this economic stressor. Our team combines expertise from psychology (Guyer, Hastings, Hostinar, Thompson), family sociology (Conger) and economics (Bitler, Page) to address these gaps by examining several questions regarding the effects of parental job loss on youth’s psychological and physical wellbeing. Our research questions are informed by the family stress model (Conger et al., 2010), which posits that adverse economic conditions can be stressful to families and that this stress can shape interactions within the family through parenting practices, parent-child interactions, and interactions between parents, which can lead to poorer health, achievement, and psychological adjustment for children. ALSPAC affords a unique opportunity to test this model through its longitudinal design, allowing us to simultaneously examine (a) associations between childhood exposure to parental job loss and psychological, physical and academic/cognitive outcomes across development, as well as (b) mediating pathways (e.g., altered parent-child interactions; children’s and parents’ stress physiology), and (c) moderators or protective factors (e.g., personality, peer relationships).