B2873 - GWAS of cognitive function - 19/04/2017

B number: 
B2873
Principal applicant name: 
Yoonsu Cho | MRC Integrative Epidemiology Unit (United Kingdom)
Co-applicants: 
Dr. Gibran Hemani, Professor George Davey Smith
Title of project: 
GWAS of cognitive function
Proposal summary: 

Cognitive functions are associated with various life outcomes. It is well known that cognitive functions are influenced by genetic variation and are heritable. The largest studies to date have been conducted by the CHARGE-Cognitive Working Group, providing large number of genetic variants. The CHARGE-Cognitive Working Group have invited ALSPAC to contribute towards their effort to perform GWAS meta-analysis on cognitive function, and they have already recruited 90,000+ samples from various other cohorts. Along with CHARGE consortium, this study is aim to investigate genetic variation that related to cognitive function using ALSPAC. This study allows ALSPAC to contribute to valuable research and to reveal more significant genetic variants by increasing sample size.

Date proposal received: 
Friday, 7 April, 2017
Date proposal approved: 
Wednesday, 12 April, 2017
Keywords: 
Genetics, Developmental disorders - autism, Cognitive impairment, Mental health, Cognitive function / Intelligence, GWAS, Statistical methods, Cognition - cognitive function, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Intelligence - memory