High blood pressure, which affects millions of people worldwide, is a major risk factor for heart attacks, stroke and chronic kidney disease. Approximately 9 million deaths each year are attributable to high blood pressure, including >50% of deaths from coronary heart disease and stroke.
Genome-wide association studies (GWAS) have identified over 50 genetic loci influencing blood pressure in European populations. However, a lot of studies have been carried out in adults, with only one study focusing on children (<18 years age). As GWAS studies require large sample sizes, we aim to replicate this study with the inclusion of more cohorts to increase statistical power.
This study in children may help us identify the underlying genetic architecture of the vascular system better compared to adults as there are very few/no confounders in terms of medication or other lifestyle factors.