B2965 - Evaluating the causal effect of gene expression on cardiovascular function - 04/10/2017

B number: 
B2965
Principal applicant name: 
Tom Richardson | MRC IEU
Co-applicants: 
Kurt Taylor, Dr Tom Gaunt, Dr Tom Richardson
Title of project: 
Evaluating the causal effect of gene expression on cardiovascular function
Proposal summary: 

Genome-wide association studies (GWAS) have uncovered hundreds of genetic variants across the human genome which influence cardiovascular disease risk. However, the underlying mechanisms which may explain these effects have yet to be explored in detail. This project aims to develop our understanding of these mechanisms by assessing changes in gene expression levels.

Date proposal received: 
Thursday, 28 September, 2017
Date proposal approved: 
Wednesday, 4 October, 2017
Keywords: 
Genetics, Obesity, Gene expression, BMI