Our understanding of adaptation in humans is currently limited to indirect methods that search for footprints of ancient selection that has acted for over thousands to millions of years in the genomes of present-day humans. We aim to take advantage of the availability of large data sets, such as ALSPAC, to identify genetic variants that impact survival in humans today. With large enough data sets, we should expect to detect small changes in the frequencies of genetic variants that happen within a few generations, i.e., directly observe natural selection in action.