B2999 - Developmental trajectories of bone mass and associations with markers of pubertal timing - 30/11/2017
B number:
B2999
Principal applicant name:
Ahmed Elhakeem | MRC Integrative Epidemiology Unit at University of Bristol
Co-applicants:
Professor Debbie Lawlor, Professor Jon Tobias
Title of project:
Developmental trajectories of bone mass and associations with markers of pubertal timing
Proposal summary:
The aim f this study is to examine the patterns of bone mass acquisition from age 9 up to age 25 years (based on measures extracted from DXA scans performed on ALSPAC index offspring at (approx.) ages 9, 11, 13, 15, 17 and 25). The study will explore sex differences in the patterns of these developmental bone mass trajectories and examine how these patterns relate to pubertal timing, specifically the age at peak height velocity and genetic markers/risk scores for timing of puberty.
Date proposal received:
Thursday, 16 November, 2017
Date proposal approved:
Wednesday, 29 November, 2017
Keywords:
Epidemiology, Bone disorders - arthritis, osteoporosis, Genomics - structural variants, Statistical methods, Bones (and joints), Cohort studies - attrition, bias, participant engagement, ethics, Childhood - childcare, childhood adversity, Development, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Growth, Metabolic - metabolism, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Puberty, Sex differences