Epilepsy is a common disorder that presents with recurrent seizures often from early childhood. It can affect children’s learning and school achievement and it is often related to other conditions such as autism, while significantly inflicting a burden on the affected children and their families. Amongst the known causes are genetic factors and birth complications. However, the mechanism by which epilepsy develops is unclear. Recent studies have found epigenetic alterations being linked with several neurological and psychiatric diseases, including scarce evidence of a link with epilepsy. Epigenetic modifications are chemical changes in the DNA molecule that maintain intact the inherited genetic information while altering, sometimes permanently, the functionality of the interested genes. Investigating these changes in the peripheral blood of children that experience seizures might help develop early biomarkers and understand the biological mechanisms behind epilepsy. In this project we aim to investigate the link between the epigenome at birth, during childhood and adolescence with the experience of seizures and we will investigate its potential consequences for neurodevelopment and mental health.