B3023 - Epigenetic gestational age and trajectories of height and weight during childhood - 18/12/2017

B number: 
B3023
Principal applicant name: 
Linda O'Keeffe | Integrative Epidemiology Unit
Co-applicants: 
Harold Bright, Dr Laura Howe, Dr Matthew Suderman
Title of project: 
Epigenetic gestational age and trajectories of height and weight during childhood
Proposal summary: 

DNA methylation is a chemical change to our DNA that influences the extent to which our genes are expressed. DNA methylation has previously been used to accurately predict age, and the difference between a person's age and the age predicted by their DNA methylation has been shown to be associated with mortality and various health outcomes. Recently, this approach has also been used to identify a set of DNA methylation markers that predict gestational age at birth (epigenetic gestational age (EGA)). EGA has been shown to be associated with birth weight, independently of gestational age, sex and ancestry. In this project, we will look at whether EGA is associated with childhood growth trajectories.

Date proposal received: 
Friday, 15 December, 2017
Date proposal approved: 
Monday, 18 December, 2017
Keywords: 
Epidemiology, epigenetics, growth, Statistical methods, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc.