B3030 - Capacity of the genome and methylome to predict BMI - 07/02/2018
B number:
B3030
Principal applicant name:
Matthew Suderman | Integrative Epidemiology Unit (Bristol)
Co-applicants:
Mr Ben Towers, Dr Gibran Hemani, Mr Thomas Battram
Title of project:
Capacity of the genome and methylome to predict BMI
Proposal summary:
Our genes influence our height, BMI and many other characteristics including susceptibility to disease. Environmental factors such as diet and stress also play a role, possibly mediated by changes in DNA methylation patterns. By analysing DNA sequence together with DNA methylation, we hope to better understand how each relates to characteristics like BMI and blood metabolite levels both separately and together.
Date proposal received:
Friday, 22 December, 2017
Date proposal approved:
Tuesday, 9 January, 2018
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Obesity, Computer simulations/modelling/algorithms, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Environment - enviromental exposure, pollution, Epigenetics, Genetics, Metabolic - metabolism