Mood and anxiety problems may increase risk of development of alcohol abuse. It is unclear to what extent genetic or environmental risk factors contribute to this relationship. This project will examine the relations between childhood mood and anxiety problems and adolescent alcohol involvement using already existing data from the Avon Longitudinal Study of Parents and Children (ALSPAC). This study includes a wealth of psychological, sociological and genetic data from around 15,000 mothers and their children (who have been followed from birth to 14 years). Analyses will take into account genotypic information (e.g., serotonergic polymorphisms) as well as environmental factors such as the children's family environment.