B444 - Genetic and environmental risk-factors for myopia in the ALSPAC study cohortLinked to B1169 - 09/01/2007

B number: 
B444
Principal applicant name: 
Dr Jez Guggenheim (University of Cardiff, UK)
Co-applicants: 
Miss Cathy E M Williams (University of Bristol, UK)
Title of project: 
Genetic and environmental risk-factors for myopia in the ALSPAC study cohort.(Linked to B1169)
Proposal summary: 

In Western countries, there are no cohorts of childhood refraction data large enough to provide the statistical power to detect subtle genetic effects (e.g. QTL controlling less than 5% of the variation in the trait phenotype). This study will provide complementary information to a moderately sized study (1400 children) in Asia, in which refraction data has been collected, and selected SNP genotyping is planned. This work will also provide preliminary data to inform a future genomewide association studies for refractive error in this cohort.

Date proposal received: 
Tuesday, 9 January, 2007
Date proposal approved: 
Tuesday, 9 January, 2007
Keywords: 
Primary keyword: