We will provide a list of 235 SNPs that have been found to be associated with performance in our cohort. We genotyped our samples using the Illumina HumanHap550 or 610 and will pick the top 10 (approximately) associations from each of the 23 phenotypes examined in our cohort for followup in the ALSPAC cohort. We would like the p-values, betas, standard errors, and direction of effect by allele for a linear regression between each of these SNPs and each of the cognition phenotypes available in the ALSPAC cohort (with covariates such as age and gender included in the model). Since our cohort is composed of individuals over the age of 18, we would prefer the cognition data to be from a timepoint past childhood.

Our analysis was done in a sample of 291 Caucasians for the following tests: Green Story Recall Immediate and Delayed, TrailsA, TrailsB, WAIS Digit Span Forward, WAIS Digit Span Backward, Controlled Oral Word Association, Animals, WAIS Digit Symbol, WAIS Symbol Search, Stroop Color-Word, and the first principal component of these 11 phenotypes. Analysis was performend in a partially overlapping sample of 656 Caucasians and Asians for the following tests from Cantab: paired associates learning (PAL) (2 phenotypes from test), spatial working memory (SWM) (2 phenotypes from test), verbal recognition memory - immediate recall (VRM), pattern recognition memory (PRM), intra-extradimensional set shifting (IED), rapid visual processing (RVP), spatial span (SSP), spatial recognition memory (SRM), and the first principal component from these 10 phenotypes. Cognition phenotypes that are most similar to these measures would be ideal for comparison.