The project will investigate the interaction between the rs9939609 SNP in the FTO gene and physical activity on the level of obesity by meta-analysing data from around 30 studies including around 140,000 individuals. The project does not require direct access to the ALSPAC data, but would require summary statistics from the analyses of the ALSPAC data according to an analysis plan which will be sent by us. Alternatively, the required variables could be sent to us, and we will carry out the required analyses.

The summary statistics we require include information on rs9939609 genotypes, physical activity, age, gender, BMI, waist circumference, and body fat percentage among the children in ALSPAC who have data from Actigraph measurements available, as well as information on the interaction between rs9939609 and physical activity on the levels of obesity, BMI, waist circumference, and body fat percentage among these children.