B856 - Effect of maternal testosterone levels on offspring 2D4D ratio - 03/08/2009

B number: 
B856
Principal applicant name: 
Dr Dave Evans (University of Bristol, UK)
Co-applicants: 
Prof George Davey Smith (University of Bristol, UK)
Title of project: 
Effect of maternal testosterone levels on offspring 2D:4D ratio.
Proposal summary: 

The SNP rs314277 in the LIN28B gene has recently been associated with age at first menarche in ALSPAC and several other population cohorts. Using genome-wide association analysis, we have recently found an association between this SNP and ratio of second to fourth digit length (2D:4D ratio) in the ALSPAC children. 2D:4D ratio is meant to be a marker of testosterone exposure in utero. I am interested in seeing whether levels of testosterone in ALSPAC mothers are correlated with offspring 2D:4D and if so whether they explain this SNP association. I am therefore asking for access to levels of testosterone and sex hormone binding globulin (SHBG) as measured in the ALSPAC mothers.

Date proposal received: 
Monday, 3 August, 2009
Date proposal approved: 
Monday, 3 August, 2009
Keywords: 
Hormones
Primary keyword: