B856 - Effect of maternal testosterone levels on offspring 2D4D ratio - 03/08/2009
B number:
B856
Principal applicant name:
Dr Dave Evans (University of Bristol, UK)
Co-applicants:
Prof George Davey Smith (University of Bristol, UK)
Title of project:
Effect of maternal testosterone levels on offspring 2D:4D ratio.
Proposal summary:
The SNP rs314277 in the LIN28B gene has recently been associated with age at first menarche in ALSPAC and several other population cohorts. Using genome-wide association analysis, we have recently found an association between this SNP and ratio of second to fourth digit length (2D:4D ratio) in the ALSPAC children. 2D:4D ratio is meant to be a marker of testosterone exposure in utero. I am interested in seeing whether levels of testosterone in ALSPAC mothers are correlated with offspring 2D:4D and if so whether they explain this SNP association. I am therefore asking for access to levels of testosterone and sex hormone binding globulin (SHBG) as measured in the ALSPAC mothers.
Date proposal received:
Monday, 3 August, 2009
Date proposal approved:
Monday, 3 August, 2009
Keywords:
Hormones
Primary keyword: