B935 - Antioxidant gene modification of the effect of prenatal paracetamol on asthma - 01/01/1900
B number:
B935
Principal applicant name:
Prof Sief Shaheen (Imperial College London, UK)
Co-applicants:
Prof John Henderson (University of Bristol, UK), Prof John Holloway (University of Southampton, UK), Dr Susan Ring (University of Bristol, UK)
Title of project:
Antioxidant gene modification of the effect of prenatal paracetamol on asthma
Proposal summary:
Having identified a possible interaction between a maternal Nrf2 SNP and prenatal paracetamol exposure on asthma risk, we would like to carry out further genotyping to confirm additional gene*paracetamol interactions.These include an additional Nrf2 SNP; GCL (relevant to glutathione synthesis); Melatonin receptor MTNR1b (melatonin is a powerful antioxidant linked to paracetamol toxicity); CYP2E1 (relevant to paracetamol toxicity).
Date proposal received:
Friday, 18 December, 2009
Date proposal approved:
Monday, 1 January, 1900
Keywords:
Allergies, Genetics, Respiratory, Atopy, Genes
Primary keyword: