This proposal aims initially to undertake meta-analyses of GWAS data for cross-sectional BP. Nicholas Timpson is representing ALSPAC with regards to the EAGLE Blood Pressure Working Group and has already agreed to complete these analyses. We are planning to run meta-analyses of cross-sectional GWAS across the participating cohorts of EAGLE which include Raine, GenR and Lisa Plus in children aged between 5 and 15 years of age.

From here we hope to identify specific SNPs and genes associated with the elevated measures SBP and DBP and additionally take these significant SNPs and investigate their association in adult blood pressure consortiums to provide further insight in to the underlying genetic determinants of adult hypertension.

We also intend to analyse both the intercept and slope of longitudinally measured BP in childhood. We will utilise a range of statistical methods, including Bayesian techniques, to investigate gene:gene interactions and longitudinal blood pressure trajectories during the postnatal period. This research will produce best linear unbiased predictors (BLUPs) for blood pressure trajectories for all eligible studies within the EAGLE Consortium for future genetic and epidemiological investigations.