B1031 - Genome-wide meta-analysis of brachial circumference - 06/09/2010

B number: 
B1031
Principal applicant name: 
Dr Ele Zeggini (Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK)
Co-applicants: 
Vesna Boraska (Not used 0, Not used 0), Dr Nic Timpson (Not used 0, Not used 0), Prof Debbie A Lawlor (Not used 0, Not used 0), Prof George Davey Smith (Not used 0, Not used 0)
Title of project: 
Genome-wide meta-analysis of brachial circumference
Proposal summary: 

RATIONALE

Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue. There are differences in the amounts of soft tissue and their pattern of distribution between genders. In addition, men have larger BC compared to women due to their larger muscle mass. Men show lower percent body fat whereas women have higher total body fat and a lower proportion of lean tissue distributed in the upper body.

The purpose of this study is to identify gender-specific and common effects underlying BC through GWAS meta-analysis on males, females and on the combined set of all individuals. Two types of association analyses will be performed: adjusted for age and adjusted for age and BMI.

ALSPAC data will add substantially to our current set of ~12k GWAS.

Date proposal received: 
Monday, 6 September, 2010
Date proposal approved: 
Monday, 6 September, 2010
Keywords: 
Genetics
Primary keyword: