B1107 - Maternal and offspring iron genes early infections and growth disentangling causality - 19/01/2011

B number: 
B1107
Principal applicant name: 
Dr Abigail Fraser (University of Bristol, UK)
Co-applicants: 
Prof Debbie A Lawlor (University of Bristol, UK), Dr Laura Howe (University of Bristol, UK), Prof Kate Tilling (University of Bristol, UK), Dr Carolina Bonilla (University of Bristol, UK), Dr Sarah J Lewis (University of Bristol, UK)
Title of project: 
Maternal and offspring iron genes, early infections and growth: disentangling causality.
Proposal summary: 

1. Assess whether there is a causal relationship between maternal iron status and offspring infection in infancy and childhood using maternal genetic variants (adjusted for offspring variants); and estimate its magnitude.

2. Assess whether there is a causal relationships between maternal iron status and offspring growth trajectories using maternal genetic variants (adjusted for offspring variants) that are robustly associated with iron status; and estimate its magnitude.

3. Unpick the direction of association between post-natal iron status (using haemoglobin measured at 8, 12 and 18 months) with childhood infections (measured at 6 and 18 months) and growth trajectories (0-5 years); and use genetic variants that are robustly associated with iron status to test for causality.

Date proposal received: 
Wednesday, 19 January, 2011
Date proposal approved: 
Wednesday, 19 January, 2011
Keywords: 
Genetics, Immunity, Infection, Nutrition
Primary keyword: