B1155 - Assessing methylome changes across adolescence in gender-related switch of asthma - 05/05/2011

B number: 
B1155
Principal applicant name: 
Prof John Holloway (University of Southampton, UK)
Co-applicants: 
Dr Hongmai Zhang (University of South Carolina, Columbia), Prof John Henderson (Not used 0, Not used 0), Prof Hasan Arshad (University of Southampton, UK), Prof Susan Ewart (University of Michigan, USA)
Title of project: 
Assessing methylome changes across adolescence in gender-related switch of asthma
Proposal summary: 

ALSPAC is one of a very few cohorts with longitudinal assessment of asthma and allergy phenotypes that has data before and after puberty coupled with samples for DNA taken before and after puberty. The application has previously been submitted to the NIH proposing to utilise samples from the 1989 Isle of Wight birth cohort alone. Utilisation of 1000 ALSPAC samples and data will enable a 2/3rds increase in sample size over the IoW cohort and significantly increase the power of the proposed analyses (the main criticism of the previous application). In addition the similar population characteristics (predominately UK Caucasian) including time frame (cojort recruitment within 3 years of each other ensuring similar environmental exposure changes over time at the population level) make ALSPAC an ideal match to the IoW cohort.

Date proposal received: 
Thursday, 5 May, 2011
Date proposal approved: 
Thursday, 5 May, 2011
Keywords: 
Allergies, Genetics, Respiratory, Atopy, Asthma, Epigenetics
Primary keyword: