B1159 - Evaluation of shared genetic determinantsfor chronic inflammatory disorders identifies novel susceptibility variants for eczema - 12/05/2011
B number:
B1159
Principal applicant name:
Dr Young-Ae Lee (Klinik f?r P?diatrie m. S. Pneumologie und Immunologie, Germany)
Co-applicants:
Prof John Henderson (Not used 0, Not used 0)
Title of project:
Evaluation of shared genetic determinants
for chronic inflammatory disorders identifies novel susceptibility variants for eczema
Proposal summary:
Project outline:
The aim of this study is to identify genetic determinants of eczema.
Genome-wide association studies (GWAS) for complex human diseases have uncovered a large number
of common genetic variants conferring moderate to low disease risk. Unfortunately, large samples sizes
are needed to detect these low-risk variants at genome-wide significance threshold required in a study
testing a large number of markers (for example 0.05 / 1 million tests = P less than 5 x10-8). Therefore, a major
challenge in the GWAS era remains the identification of true risk factors among the
Date proposal received:
Thursday, 12 May, 2011
Date proposal approved:
Thursday, 12 May, 2011
Keywords:
Eczema, Genetics
Primary keyword: