B1178 - Following up findings from a genome-wide association study of attention-deficit hyperactivity disorder and associated conduct - 09/06/2011

B number: 
B1178
Principal applicant name: 
Dr Evangelia Stergiakouli (University of Cardiff, UK)
Co-applicants: 
Dr Martin Hamshere (Not used 0, Not used 0), Prof Peter Holmans (Not used 0, Not used 0), Dr Joanna Martin (Not used 0, Not used 0), Dr Kate Langley (Not used 0, Not used 0), Dr Nigel Williams (Not used 0, Not used 0)
Title of project: 
Following up findings from a genome-wide association study of attention-deficit hyperactivity disorder and associated conduct
Proposal summary: 

Project outline:

A genome-wide association study of ADHD using antisocial behaviour as an index of heterogeneity

Introduction

ADHD is a highly heritable disorder that is of unknown pathogenesis (Stergiakouli & Thapar, 2010; Faraone et al, 2005). ADHD shows clinical as well as aetiological heterogeneity and the presence of antisocial behaviour (ASB) in children with ADHD is known to be an important marker of heterogeneity. It indexes greater clinical severity, poorer outcome, persistent problems in adulthood, stronger association with neurocognitive deficits and higher familial and genetic loading. Previous candidate gene studies have also suggested that the presence of ASB indexes heterogeneity (Langley et al, 2010).

In our ADHD programme grant we set out to identify ADHD susceptibility genes and also test for the effects of comorbid conduct disorder symptoms.

We have recently completed the genome-wide association study in a well-characterised sample of 727 children with DSM-IV/III-R diagnosed ADHD and 5,081 controls. We have tested for association between 1) SNPs and ADHD, 2) SNPs and Conduct disorder in children with ADHD.

Date proposal received: 
Thursday, 9 June, 2011
Date proposal approved: 
Thursday, 9 June, 2011
Keywords: 
ADHD, Antisocial Behaviour
Primary keyword: