B1192 - Effects of maternal vitamin D status in pregnancy on DNA methylation patterns at birth association with phenotypes - 23/06/2011

B number: 
B1192
Principal applicant name: 
Dr Caroline Relton (Not used 0, Not used 0)
Co-applicants: 
Eva Morales (Not used 0, Not used 0), Prof Debbie A Lawlor (Not used 0, Not used 0)
Title of project: 
Effects of maternal vitamin D status in pregnancy on DNA methylation patterns at birth: association with phenotypes
Proposal summary: 

Objectives

To assess DNA methylation changes in cord blood in relation to maternal vitamin D status during pregnancy.

To investigate if changes in DNA methylation at birth predict phenotypes in childhood. Selected phenotypes could include: cognition/ADHD symptoms, asthma-related phenotypes and obesity.

If sample size adequate we could perform a mendelian randomization approach using maternal polymorphism associated with vitamin D levels.

Date proposal received: 
Thursday, 23 June, 2011
Date proposal approved: 
Thursday, 23 June, 2011
Keywords: 
Parenting, Epigenetics , Vitamin D
Primary keyword: