Hair and eye color show a high degree of variation in people of European ancestry and correlate with latitude within the European continent, which may be explained by a combination of natural and sexual selection. The inheritance of hair and eye color is not strictly Mendelian although blue iris color follows largely a recessive pattern. Genome-wide association studies in people of Europeans decent have confirmed eye color as a polygenic trait, with the HERC2/OCA2 genes explaining the most of the blue and brown eye color inheritance, whereas other genes such as SLC2A4, TYR, TYRP1, SLC45A2, and IRF4 contribute additionally to eye color variation, albeit with minor effects. The purpose of this proposal is to perform genome-wide association analysis on the hair and eye colour measures within the ALSPAC cohort and to combine these with the results from other cohorts in a genome-wide association meta-analysis. Summary data consisting of association statistics and genotype counts will be shared with other cohorts.