A number of genetic variants associated with adiposity traits (BMI, Waist and Waist to Hip Ratio) have been identified. Yet there is still unexplained heritability in these traits. In addition, smoking is known to affect adiposity traits. Our efforts are to identify genetic variants that modify the effects of smoking on adiposity traits. We are conducting this research in the GIANT Consortium and collectively summarizing the results of more than 70,000 individuals. Large samples are needed to detect such interaction effects. And so any study that can contribute results to this effort is welcome.