B1365 - Relationship between empirically-based candidate SNPs for major neuropsychiatric disease and quantitative trait variation - 10/05/2012
B number:
B1365
Principal applicant name:
Elise Robinson (Harvard School of Public Health, USA)
Co-applicants:
Mark J Daly (Harvard School of Public Health, USA), Angelica Ronald (Harvard School of Public Health, USA)
Title of project:
Relationship between empirically-based candidate SNPs for major neuropsychiatric disease and quantitative trait variation
Proposal summary:
Aims- This project is designed to estimate the relationship between variation in SNPs recently identified as risk factors for major neuropsychiatric diseases and cognitive/behavioral phenotypes in the general population. The SNPs requested below were identified as candidates in the Psychiatric GWAS Consortium analyses. Hypotheses- Common genetic variants that have been associated with major neuropsychiatric diseases (e.g. schizophrenia, bipolar disorder) will be associated with a continuous shift towards impairment in the distribution of cognitive and behavioral abilities in the general population. For example, variation in SNPs associated with schizophrenia will predict mean differences in IQ in the general population.
Date proposal received:
Thursday, 10 May, 2012
Date proposal approved:
Thursday, 10 May, 2012
Keywords:
Genetics, Mental Health, Cognitive Function
Primary keyword: