A longitudinal study starting in pregnancy is needed in order to determine if dietary patterns, or fatty acid deficiencies or excesses, increase risk of self harm and significant symptoms of anxiety in the perinatal period. Fatty acid compositional data from mothers and from umbilical cord has already been provided. Within this population, minor alleles of the FADS 1-2 gene complex have been shown to associate with functional deficits in fatty acid metabolism corresponding to the delta 5 and delta 6 desaturases. Dietary patterns covary with essential fatty acid status and may be critical determinants. These fatty acids act as precursors for endogenous cannabinoids, which are implicated in depression anxiety and suicideal behaviors. Gene variants in the endocannabinoid pathway will be evaluated for association with self harm phenotypes. Data characterizing self harm phenotypes are available for development. No other study has this complement of datasets in a large well characterized representative population. This work is a continuation of analysis of existing data in project B275.