This proposal will examine the prospective association between antisocial behavior in childhood with increased cardiometabolic risk in adolescence.

Specific aims:

1. To test whether childhood psychopathology, including antisocial behavior and conduct disorder predict higher cardiometabolic risk in adolescence as indicated by higher central obesity, hypertension, glucose intolerance, and high levels of inflammation markers.

2. To examine whether a prospective association between conduct disorder in childhood and cardiometabolic risk in adolescence varies by gender.

3.To examine whether a prospective association between conduct disorder in childhood and cardiometabolic risk in adolescence is modified by comorbidity with depression.

Exposure variables: Antisocial behavior, conduct disorder in childhood

Outcome variables: Blood presure, BMI, central adiposity, glucose intolerance, lipids profile, CRP, IL6 at ages 14-16

Covariates (confounders and effect modifiers): Depression, trauma, emotional problems, social class, IQ, parenting, psychosocial stress in pregnancy, parental history of psychiatric disorders and substance use, parental history of cardiometabolic disorders.